Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh JY
PROVIDER: S-EPMC7847962 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
iScience 20210113 2
Human mitochondrial NAD(P)<sup>+</sup>-dependent malic enzyme (ME2) is well recognized to associate with cancer cell metabolism, and the single nucleotide variants (SNVs) of ME2 may play a role in enzyme regulation. Here we reported that the SNVs of ME2 occurring in the allosteric sites lead to inactivation or overactivation of ME2. Two ME2-SNVs, ME2_R67Q and ME2-R484W, that demonstrated inactivating or overactivating enzyme activities of ME2, respectively, have different impact toward the cells ...[more]