Anemia, iron deficiency, and cobalamin deficiency in cats with chronic gastrointestinal disease.

ABSTRACT:

Background

Iron deficiency and cobalamin deficiency, as sequelae to chronic gastrointestinal (GI) disease, could result in anemia and increased morbidity in cats with chronic enteropathies.

Objective

To evaluate iron deficiency in cats with chronic GI disease and its relationship with hypocobalaminemia, anemia, and disease severity.

Animals

Twenty client-owned cats with primary GI disease.

Methods

Prospective, cross-sectional study. Cats were enrolled at the time of evaluation for chronic GI disease, after exclusion of comorbidities. CBC with reticulocyte indices, iron metabolism (serum iron and ferritin concentrations, total iron binding capacity [TIBC]), serum methylmalonic acid (MMA), cobalamin, and folate concentrations, pancreatic lipase and trypsin-like immunoreactivity, and disease severity were evaluated.

Results

Anemia (hematocrit <30%), iron deficiency, and cobalamin deficiency were diagnosed in 4/20, 7/20, and 8/20 cats, respectively. Hematocrit (r_s =?-.45; P s =?-.60; P s =?.51; P =?.02), reticulocyte MCV (r_s =?.52; P =?.02), reticulocyte hemoglobin content (r_s =?.71; P s =?.79; P Conclusions and clinical importanceFunctional iron deficiency was common in cats with chronic GI disease. Associations between hypocobalaminemia, iron parameters, and hematologic parameters warrant further investigation on the impact of iron deficiency on chronic GI disease morbidity in cats.

SUBMITTER: Hunt A 

PROVIDER: S-EPMC7848310 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature