Dataset Information

Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on electrolyte and acid-base variables in dogs with suspected intracranial hypertension.

ABSTRACT:

Background

Hyperosmolar agents frequently are used to decrease intracranial pressure but their effects on electrolyte and acid-base variables have not been prospectively investigated.

Objectives

Compare duration and magnitude of changes in electrolyte and acid-base variables after hyperosmolar treatment.

Animals

Twenty-eight client-owned dogs with intracranial hypertension caused by various pathologies.

Methods

Prospective, randomized, nonblinded, experimental cohort study. Fifteen dogs received a single dose (4 mL/kg) of 7.2% hypertonic saline (HTS), 13 dogs received 20% mannitol (MAN) 1 g/kg IV. Electrolyte and acid-base variables were measured before (T₀ ), and 5 (T₅ ), 60 (T₆₀ ), and 120 (T₁₂₀ ) minutes after administration. Variables were compared between treatments and among time points within treatment groups.

Results

Mean plasma sodium and chloride concentrations were higher after HTS than MAN at T₅ (158 vs 141?mEq/L; 126 vs 109?mEq/L) and significant differences were maintained at all time points. After HTS, plasma sodium and chloride concentrations remained increased from T₀ at all time points. After MAN, plasma sodium and chloride concentrations decreased at T₅ , but these changes were not maintained at T₆₀ and T₁₂₀ . Plasma potassium concentration was lower at T₅ after HTS compared with T₀ (3.6 vs 3.9?mEq/L) and compared to MAN (3.6 vs 4.1?mEq/L). At T₆₀ and T₁₂₀ , plasma ionized calcium concentration was lower after HTS than MAN (1.2 vs 1.3?mmol/L). No significant differences were found in acid-base variables between treatments.

Conclusions and clinical importance

At the administered dose, dogs receiving HTS showed sustained increases in plasma sodium and chloride concentrations, whereas dogs receiving MAN showed transient decreases. Future studies should assess the effects of multiple doses of hyperosmolar agents on electrolyte and acid-base variables.

SUBMITTER: Hoehne SN

PROVIDER: S-EPMC7848367 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on electrolyte and acid-base variables in dogs with suspected intracranial hypertension.

Hoehne Sabrina N SN Yozova Ivayla D ID Vidondo Beatriz B Adamik Katja N KN

Journal of veterinary internal medicine 20201125 1

<h4>Background</h4>Hyperosmolar agents frequently are used to decrease intracranial pressure but their effects on electrolyte and acid-base variables have not been prospectively investigated.<h4>Objectives</h4>Compare duration and magnitude of changes in electrolyte and acid-base variables after hyperosmolar treatment.<h4>Animals</h4>Twenty-eight client-owned dogs with intracranial hypertension caused by various pathologies.<h4>Methods</h4>Prospective, randomized, nonblinded, experimental cohort ...[more]

PMID: 33236379

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Dataset Information

Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on electrolyte and acid-base variables in dogs with suspected intracranial hypertension.

Background

Objectives

Animals

Methods

Results

Conclusions and clinical importance

Publications

Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on electrolyte and acid-base variables in dogs with suspected intracranial hypertension.

Similar Datasets

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