Dataset Information

Retrospective study of dilated cardiomyopathy in dogs.

ABSTRACT:

Background

The United States Food and Drug Administration is investigating possible diet-associated dilated cardiomyopathy (DCM) in dogs and cats.

Objectives

To retrospectively review DCM cases for signalment, diet information, echocardiographic changes, and survival.

Animals

Client-owned dogs (n = 71).

Methods

Medical records of dogs diagnosed with DCM between January 1, 2014 and September 30, 2018 were reviewed. Dogs were grouped into "traditional" or "nontraditional" diet categories and whether or not diet was changed after diagnosis.

Results

For dogs eating nontraditional diets, those that had their diets changed had a larger percentage decrease in normalized systolic left ventricular internal dimension (P = .03) and left atrial:aorta ratio (P?Conclusions and clinical importanceDogs with DCM eating nontraditional diets can experience improvement in cardiac function after diet change but additional research is needed to examine possible associations between diet and DCM.

SUBMITTER: Freid KJ

PROVIDER: S-EPMC7848368 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Retrospective study of dilated cardiomyopathy in dogs.

Freid Kimberly J KJ Freeman Lisa M LM Rush John E JE Cunningham Suzanne M SM Davis Megan S MS Karlin Emily T ET Yang Vicky K VK

Journal of veterinary internal medicine 20201221 1

<h4>Background</h4>The United States Food and Drug Administration is investigating possible diet-associated dilated cardiomyopathy (DCM) in dogs and cats.<h4>Objectives</h4>To retrospectively review DCM cases for signalment, diet information, echocardiographic changes, and survival.<h4>Animals</h4>Client-owned dogs (n = 71).<h4>Methods</h4>Medical records of dogs diagnosed with DCM between January 1, 2014 and September 30, 2018 were reviewed. Dogs were grouped into "traditional" or "nontradition ...[more]

PMID: 33345431

Similar Datasets

Project description:BackgroundWith the recent advances in the treatment of heart failure (HF), it is intriguing that a very small number of patients with dilated cardiomyopathy (DCM) have been observed as being fully recovered. However, knowledge of the progression and prognosis of patients with recovered DCM remains sparse. Herein, we conducted this study to investigate the clinical characteristics and prognosis of patients with recovered DCM.MethodsConsecutive patients with recovered DCM referred to our hospital between March 2009 and May 2021 were included. The recovered DCM patients were categorized into relapse and non-relapse groups. The primary endpoint was all-cause death, and the secondary endpoint was HF re-hospitalization during follow-up. Multivariate analyses were performed to identify predictors of relapse among recovered DCM patients. Kaplan-Meier analyses were used to assess the prognostic significance of relapse.ResultsA comparatively large cohort of 122 recovered DCM patients from 10,029 DCM patients was analyzed. During a median follow-up duration of 53.5 months, the relapse rate among recovered DCM patients was 15.6% (19/122). Age (odds ratio, OR 1.079, 95% confidence interval, CI: 1.014-1.148; p = 0.017), systolic blood pressure (SBP) at diagnosis (OR 0.948, 95% CI: 0.908-0.990; p = 0.015) and changes in left ventricular ejection fraction from diagnosis to recovery ( Δ LVEF) (OR 0.898, 95% CI: 0.825-0.978; p = 0.013) were identified as predictors of relapse. Furthermore, among 122 patients, 5 (4.1%) experienced death, and 12 (9.8%) underwent HF re-hospitalization. Four deaths occurred in the relapse group, with one in the non-relapse group. All deaths were attributed to cardiovascular events. The long-term prognosis of the relapse group was significantly worse compared to the non-relapse group by Kaplan-Meier analysis (p < 0.001 based on the log-rank test). Multivariate analyses significantly associated relapse with all-cause mortality in recovered DCM patients (hazard ratio, HR 7.738, 95% CI: 1.892-31.636; p = 0.004).ConclusionsRecovered DCM patients are at risk of relapse. Older age, lower SBP, and smaller Δ LVEF were independently associated with relapse in recovered DCM patients. Relapse after recovery was related to an unfavorable long-term prognosis.

Dataset Information

Retrospective study of dilated cardiomyopathy in dogs.

Background

Objectives

Animals

Methods

Results

Publications

Retrospective study of dilated cardiomyopathy in dogs.

Similar Datasets

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