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Frontoparietal and default mode network connectivity varies with age and intelligence.


ABSTRACT:

Background

Anticorrelated resting state connectivity between task-positive and task-negative networks in adults supports flexible shifting between externally focused attention and internal thought. Findings suggest that children show positive correlations between task-positive (frontoparietal; FP) and task-negative (default mode; DMN) networks. FP-DMN connectivity also associates with intellectual functioning across the lifespan. We investigated whether FP-DMN connectivity in healthy children varied with age and intelligence quotient (IQ).

Methods

We utilized network-based statistics (NBS) to examine resting state functional connectivity between FP and DMN seeds in N = 133 7-25-year-olds (Mage = 15.80). Linear regression evaluated FP-DMN associations with IQ.

Results

We detected NBS subnetworks containing both within- and between-network connections that were inversely associated with age. Four FP-DMN connections showed more negative connectivity between FP (inferior frontal gyrus and precentral gyrus) and DMN regions (frontal medial cortex, precuneus, and frontal pole) among older participants. Frontal pole-precentral gyrus connectivity inversely associated with IQ.

Conclusions

FP-DMN connectivity was more anticorrelated at older ages, potentially indicating dynamic network segregation of these circuits from childhood to early adulthood. Youth with more mature (i.e., anticorrelated) FP-DMN connectivity demonstrated higher IQ. Our findings add to the growing body of literature examining neural network development and its association with IQ.

SUBMITTER: DeSerisy M 

PROVIDER: S-EPMC7848769 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Frontoparietal and default mode network connectivity varies with age and intelligence.

DeSerisy Mariah M   Ramphal Bruce B   Pagliaccio David D   Raffanello Elizabeth E   Tau Gregory G   Marsh Rachel R   Posner Jonathan J   Margolis Amy E AE  

Developmental cognitive neuroscience 20210127


<h4>Background</h4>Anticorrelated resting state connectivity between task-positive and task-negative networks in adults supports flexible shifting between externally focused attention and internal thought. Findings suggest that children show positive correlations between task-positive (frontoparietal; FP) and task-negative (default mode; DMN) networks. FP-DMN connectivity also associates with intellectual functioning across the lifespan. We investigated whether FP-DMN connectivity in healthy chi  ...[more]

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