Unknown

Dataset Information

0

Accelerated maturation in functional connectivity following early life stress: Circuit specific or broadly distributed?


ABSTRACT: Psychosocial acceleration theory and other frameworks adapted from life history predict a link between early life stress and accelerated maturation in several physiological systems. Those findings led researchers to suggest that the emotion-regulatory brain circuits of previously-institutionalized (PI) youth are more mature than youth raised in their biological families (non-adopted, or NA, youth) during emotion tasks. Whether this accelerated maturation is evident during resting-state fMRI has not yet been established. Resting-state fMRI data from 83 early adolescents (Mage = 12.9 years, SD = 0.57 years) including 41 PI and 42 NA youth, were used to examine seed-based functional connectivity between the amygdala and ventromedial prefrontal cortex (vmPFC). Additional whole-brain analyses assessed group differences in functional connectivity and associations with cognitive performance and behavior. We found group differences in amygdala - vmPFC connectivity that may be consistent with accelerated maturation following early life stress. Further, whole-brain connectivity analyses revealed group differences associated with internalizing and externalizing symptoms. However, the majority of whole-brain results were not consistent with an accelerated maturation framework. Our results suggest early life stress in the form of institutional care is associated with circuit-specific alterations to a frontolimbic emotion-regulatory system, while revealing limited differences in more broadly distributed networks.

SUBMITTER: Herzberg MP 

PROVIDER: S-EPMC7848776 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Accelerated maturation in functional connectivity following early life stress: Circuit specific or broadly distributed?

Herzberg Max P MP   McKenzie Kelly Jedd KJ   Hodel Amanda S AS   Hunt Ruskin H RH   Mueller Bryon A BA   Gunnar Megan R MR   Thomas Kathleen M KM  

Developmental cognitive neuroscience 20210120


Psychosocial acceleration theory and other frameworks adapted from life history predict a link between early life stress and accelerated maturation in several physiological systems. Those findings led researchers to suggest that the emotion-regulatory brain circuits of previously-institutionalized (PI) youth are more mature than youth raised in their biological families (non-adopted, or NA, youth) during emotion tasks. Whether this accelerated maturation is evident during resting-state fMRI has  ...[more]

Similar Datasets

| S-EPMC6527488 | biostudies-literature
| S-EPMC6399387 | biostudies-literature
| S-EPMC4894492 | biostudies-other
| S-EPMC8247254 | biostudies-literature
| S-EPMC5010940 | biostudies-literature
| S-EPMC6838553 | biostudies-literature
| S-EPMC6869775 | biostudies-literature
| S-EPMC4915263 | biostudies-literature
| S-EPMC5820270 | biostudies-literature
| S-EPMC6202577 | biostudies-literature