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Potential Mobilization of mcr-10 by an Integrative Mobile Element via Site-Specific Recombination in Cronobacter sakazakii.


ABSTRACT: mcr-10 is a newly identified plasmid-borne colistin resistance gene, but its mobilization mechanism remains unclear. In this study, mcr-10 was found on an IncFIB plasmid carrying virulence genes mrkABCDFJ, iucABCD/iutA, and eitCBAD in a Cronobacter sakazakii isolate. By comparison with closely related plasmids, two recombination sites were identified flanking the genetic element containing mcr-10 and an integrase-encoding gene, suggesting that site-specific recombination mediated by an integrase of an integrative mobile element is a potential mechanism for mobilizing mcr-10.

SUBMITTER: Yang J 

PROVIDER: S-EPMC7849017 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Potential Mobilization of <i>mcr-10</i> by an Integrative Mobile Element via Site-Specific Recombination in Cronobacter sakazakii.

Yang Jing J   Liu Lina L   Feng Yu Y   He Da D   Wang Chengcheng C   Zong Zhiyong Z  

Antimicrobial agents and chemotherapy 20210120 2


<i>mcr-10</i> is a newly identified plasmid-borne colistin resistance gene, but its mobilization mechanism remains unclear. In this study, <i>mcr-10</i> was found on an IncFIB plasmid carrying virulence genes <i>mrkABCDFJ</i>, <i>iucABCD</i>/<i>iutA</i>, and <i>eitCBAD</i> in a <i>Cronobacter sakazakii</i> isolate. By comparison with closely related plasmids, two recombination sites were identified flanking the genetic element containing <i>mcr-10</i> and an integrase-encoding gene, suggesting t  ...[more]

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