Ontology highlight
ABSTRACT:
SUBMITTER: Bedrosian TA
PROVIDER: S-EPMC7849303 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20201210 3
Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age-dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age-related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature ...[more]