Dataset Information

STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.

ABSTRACT:

Aim

A prospective investigation of serum thymidine kinase 1 concentration (STK1p) was performed to evaluate its prognostic value in patients with non-small-cell lung carcinoma (NSCLCs).

Patients & methods

The STK1p values of 127 patients were determined by an enhanced chemiluminescent dot blot assay. The patients were recruited from March 2011 to December 2017.

Results

Kaplan-Meier plot showed that patients with elevated STK1p values had worse overall survival (OS), especially patients of early/middle stages. Multi-variable COX regression showed that STK1p value and combined treatment surgery + chemotherapy were independent prognostic factors for favorable OS.

Conclusion

STK1p is helpful in predicting OS of early/middle stages (I-IIIA) NSCLCs patients following a nonrandomized individual adapted treatment, but is may be not recommended in advanced stages (IIIB + IV) of NSCLCs.

SUBMITTER: Wang Z

PROVIDER: S-EPMC7849927 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.

Wang Zhenxin Z Zhang Guoqing G Li Zhongcheng Z Li Jin J Ma Hongbo H Hei Ailian A Jiao Shunchang S Hu Yi Y Sun Shengjie S Wu Liangliang L Zhou Ji J Wang Yu Y He Ellen E Skog Sven S

Future science OA 20201123 3

<h4>Aim</h4>A prospective investigation of serum thymidine kinase 1 concentration (STK1p) was performed to evaluate its prognostic value in patients with non-small-cell lung carcinoma (NSCLCs).<h4>Patients & methods</h4>The STK1p values of 127 patients were determined by an enhanced chemiluminescent dot blot assay. The patients were recruited from March 2011 to December 2017.<h4>Results</h4>Kaplan-Meier plot showed that patients with elevated STK1p values had worse overall survival (OS), especia ...[more]

PMID: 33552542

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Dataset Information

STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.

Aim

Patients & methods

Results

Conclusion

Publications

STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.

Similar Datasets

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