Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response.

ABSTRACT:

Background

Cisplatin-induced peripheral neuropathy (CIPN) is a frequent serious dose-dependent adverse event that can determine dosage limitations for cancer treatment. CIPN severity correlates with the amount of platinum detected in sensory neurons of the dorsal root ganglia (DRG). However, the exact pathophysiology of CIPN is poorly understood, so the chance of developing neuroprotective treatment is reduced. The aim of this study was to determine the exact mechanisms involved in CIPN development.

Methods

By single-cell RNA-sequencing (scRNAseq), we have studied the transcriptomic profile of DRG sensory neurons from a well-characterized neurophysiological mouse model of CIPN.

Results

Gene Ontology analysis of the scRNAseq data indicated that cisplatin treatment indu

SUBMITTER: Calls A 

PROVIDER: S-EPMC7850121 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature