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Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans.

ABSTRACT: Orcokinin neuropeptides are conserved among ecdysozoans, but their functions are incompletely understood. Here, we report a role for orcokinin neuropeptides in the regulation of sleep in the nematode Caenorhabditis elegans. The C. elegans orcokinin peptides, which are encoded by the nlp-14 and nlp-15 genes, are necessary and sufficient for quiescent behaviors during developmentally timed sleep (DTS) as well as during stress-induced sleep (SIS). The five orcokinin neuropeptides encoded by nlp-14 have distinct but overlapping functions in the regulation of movement and defecation quiescence during SIS. We suggest that orcokinins may regulate behavioral components of sleep-like states in nematodes and other ecdysozoans.

SUBMITTER: Honer M

PROVIDER: S-EPMC7850316 | biostudies-literature | 2020 Sep-Dec

REPOSITORIES: biostudies-literature

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Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans.

Honer Madison M Buscemi Kristen K Barrett Natalie N Riazati Niknaz N Orlando Gerald G Nelson Matthew D MD

Journal of neurogenetics 20200901 3-4

Orcokinin neuropeptides are conserved among ecdysozoans, but their functions are incompletely understood. Here, we report a role for orcokinin neuropeptides in the regulation of sleep in the nematode Caenorhabditis elegans. The C. elegans orcokinin peptides, which are encoded by the nlp-14 and nlp-15 genes, are necessary and sufficient for quiescent behaviors during developmentally timed sleep (DTS) as well as during stress-induced sleep (SIS). The five orcokinin neur ...[more]

PMID: 33044108

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