Dose, Timing, and Spectrum of Prenatal Antibiotic Exposure and Risk of Childhood Asthma.

ABSTRACT:

Background

The potential for prenatal antibiotic exposure to influence asthma risk is not clear. We aimed to determine the effect of timing, dose, and spectrum of prenatal antibiotic exposure on the risk of childhood asthma.

Methods

We conducted a population-based cohort study of 84 214 mother-child dyads to examine the association of prenatal antibiotic exposure and childhood asthma using multivariable logistic regression models.

Results

Sixty-four percent of pregnant women received antibiotics. Prenatal antibiotic exposure was associated dose-dependently with increased odds of childhood asthma (adjusted odds ratio [aOR] for interquartile increase of 2 courses [interquartile range, 0-2], 1.26 [95% confidence interval {CI}, 1.20-1.33]). Among children exposed to at le

SUBMITTER: Turi KN 

PROVIDER: S-EPMC7850553 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature