Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7851084 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Lei L Wang Tao T Li Shanbao S Chen Zhengqian Z Wu Junyi J Cao Wanyue W Wo Qi Q Qin Xuebin X Xu Junming J
Frontiers in oncology 20210119
Tryptophan 2,3-dioxygenase (TDO2), an enzyme involved in tryptophan (Trp) metabolism has been linked with some malignant traits of various cancers. Kyn, the main product of Trp metabolism pathway catalyzed by TDO2 and indoleamine 2,3-dioxygenase (IDO) in tumor cells, was also demonstrated to activate aryl hydrocarbon receptor (AhR), which may regulate cancer growth and invasion in some malignancies. However, whether TDO2 participates in the metastasis and invasion of HCC has not been explored be ...[more]