Ontology highlight
ABSTRACT:
SUBMITTER: Valero C
PROVIDER: S-EPMC7851155 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Valero Cristina C Lee Mark M Hoen Douglas D Weiss Kate K Kelly Daniel W DW Adusumilli Prasad S PS Paik Paul K PK Plitas George G Ladanyi Marc M Postow Michael A MA Ariyan Charlotte E CE Shoushtari Alexander N AN Balachandran Vinod P VP Hakimi A Ari AA Crago Aimee M AM Long Roche Kara C KC Smith J Joshua JJ Ganly Ian I Wong Richard J RJ Patel Snehal G SG Shah Jatin P JP Lee Nancy Y NY Riaz Nadeem N Wang Jingming J Zehir Ahmet A Berger Michael F MF Chan Timothy A TA Seshan Venkatraman E VE Morris Luc G T LGT
Nature communications 20210201 1
Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients experience clinical benefit, there is a strong need for biomarkers that are easily accessible across diverse practice settings. Here, in a retrospective cohort study of 1714 patients with 16 different cancer types treated with ICI, we show that higher neutrophil-to-lymphocyte ratio (NLR) is significantly associated with poorer overall and progres ...[more]