Value of Patlak Ki images from ¹⁸F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis.

ABSTRACT: The association between ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of ¹⁸F-FDG uptake is a quantitative index of ¹⁸F-FDG metabolism. This study aims to investigate the usefulness of standardized uptake value (SUV) and Patlak Ki images (Ki images) extracted from dynamic ¹⁸F-FDG-PET/CT for evaluating the risk of clinical events (CEs) in CS. The SUV and Ki myocardial images were generated from 30 dynamic ¹⁸F-FDG-PET/CT scans of 21 CS patients. The SUV and Ki images both were rated as positive in 19 scans and negative in 11 scans with the same incidence of CEs which were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11); arrhythmic events: 65.5% (10/19) vs. 0% (0/11)]. In 19 positive scans, the three Ki parameters (Ki max, Ki mean and Ki volume) were significantly higher in scans for patients with arrhythmic events than in those without. Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events. Our study suggests that Ki images may add value to SUV images for evaluating the risk of CEs in CS patients.

SUBMITTER: Nakajo M 

PROVIDER: S-EPMC7851386 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature