Ontology highlight
ABSTRACT:
SUBMITTER: McGuire JJ
PROVIDER: S-EPMC7851397 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
McGuire Jeremy J JJ Frieling Jeremy S JS Lo Chen Hao CH Li Tao T Muhammad Ayaz A Lawrence Harshani R HR Lawrence Nicholas J NJ Cook Leah M LM Lynch Conor C CC
Nature communications 20210201 1
Bone metastatic prostate cancer (PCa) promotes mesenchymal stem cell (MSC) recruitment and their differentiation into osteoblasts. However, the effects of bone-marrow derived MSCs on PCa cells are less explored. Here, we report MSC-derived interleukin-28 (IL-28) triggers prostate cancer cell apoptosis via IL-28 receptor alpha (IL-28Rα)-STAT1 signaling. However, chronic exposure to MSCs drives the selection of prostate cancer cells that are resistant to IL-28-induced apoptosis and therapeutics su ...[more]