In silico characterization and structural modeling of bacterial metalloprotease of family M4.

ABSTRACT:

Background

The M4 family of metalloproteases is comprised of a large number of zinc-containing metalloproteases. A large number of these enzymes are important virulence factors of pathogenic bacteria and therefore potential drug targets. Whereas some enzymes have potential for biotechnological applications, the M4 family of metalloproteases is known almost exclusively from bacteria. The aim of the study was to identify the structure and properties of M4 metalloprotease proteins.

Results

A total of 31 protein sequences of M4 metalloprotease retrieved from UniProt representing different species of bacteria have been characterized for various physiochemical properties. They were thermostable, hydrophillic protein of a molecular mass ranging from 38 to 66 KDa. Correlation on the

SUBMITTER: Hasan R 

PROVIDER: S-EPMC7851659 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature