Type of atrial fibrillation and outcomes in patients without oral anticoagulants.

ABSTRACT:

Background

The effect of type of atrial fibrillation (AF) on adverse outcomes in Chinese patients without oral anticoagulants (OAC) was controversial.

Hypothesis

The type of AF associated with adverse outcomes in Chinese patients without OAC.

Methods

A total of 1358 AF patients without OAC from a multicenter, prospective, observational study was included for analysis. Univariable and multivariable Cox regression models were utilized. Net reclassification improvement analysis was performed for the assessment of risk prediction models.

Results

There were 896(66%) patients enrolled with non-paroxysmal AF (NPAF) and 462(34%) with paroxysmal AF (PAF). The median age was 70.9?±?12.6?years, and 682 patients (50.2%) were female. During 1 year of follow-up, 215(16.4%) patients died, and 107 (8.1%) patients experienced thromboembolic events. Compared with the PAF group, NPAF group had a notably higher incidence of all-cause mortality (20.2% vs. 9.4%, p?2 DS₂ -VASc score allowed an improvement of 0.37 in risk prediction for thromboembolic events (95% CI 0.21-0.53; p?ConclusionsIn Chinese AF patients who were not on OAC, NPAF was an independent predictor of thromboembolism and mortality. The addition of NPAF to the CHA₂ DS₂ -VASc score allowed an improvement in the accuracy of the prediction of thromboembolic events.

SUBMITTER: Ren J 

PROVIDER: S-EPMC7852164 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature