Ontology highlight
ABSTRACT:
SUBMITTER: Shen X
PROVIDER: S-EPMC7852228 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Shen Xiaoying X Tang Haili H McDanal Charlene C Wagh Kshitij K Fischer Will W Theiler James J Yoon Hyejin H Li Dapeng D Haynes Barton F BF Sanders Kevin O KO Gnanakaran Sandrasegaram S Hengartner Nick N Pajon Rolando R Smith Gale G Dubovsky Filip F Glenn Gregory M GM Korber Bette B Montefiori David C DC
bioRxiv : the preprint server for biology 20210129
The SARS-CoV-2 Spike glycoprotein mediates virus entry and is a major target for neutralizing antibodies. All current vaccines are based on the ancestral Spike with the goal of generating a protective neutralizing antibody response. Several novel SARS-CoV-2 variants with multiple Spike mutations have emerged, and their rapid spread and potential for immune escape have raised concerns. One of these variants, first identified in the United Kingdom, B.1.1.7 (also called VUI202012/01), contains eigh ...[more]