Ontology highlight
ABSTRACT:
SUBMITTER: Shook BA
PROVIDER: S-EPMC7853423 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cell stem cell 20200416 6
Mature adipocytes store fatty acids and are a common component of tissue stroma. Adipocyte function in regulating bone marrow, skin, muscle, and mammary gland biology is emerging, but the role of adipocyte-derived lipids in tissue homeostasis and repair is poorly understood. Here, we identify an essential role for adipocyte lipolysis in regulating inflammation and repair after injury in skin. Genetic mouse studies revealed that dermal adipocytes are necessary to initiate inflammation after injur ...[more]