Dataset Information

White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.

ABSTRACT:

Objectives

This study aimed to clarify the relationship between the white blood cell (WBC) count and hypertension in the general Japanese population.

Methods

We conducted a population-based retrospective cohort study using annual health check-up data of residents of Iki City, Nagasaki Prefecture, Japan. A total of 2935 participants without hypertension at baseline were included in the present analysis. WBC counts were classified as tertile 1 (<4700/?L), tertile 2 (4700-5999/?L), and tertile 3 (?6000/?L). The outcome was incident hypertension (blood pressure ?140 mmHg). Multivariable-adjusted hazard ratios and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazards model.

Result

During an average follow-up of 4.5 years, 908 participants developed hypertension. The incidence (per 100 person-years) of hypertension increased with an elevation in the WBC count (6.3 in tertile 1, 7.0 in tertile 2, and 7.4 in tertile 3). This association was significant, even after adjustment for other risk factors, including age, sex, current smoking habits, current alcohol intake, exercise habits, obesity, elevated blood pressure, diabetes mellitus, and dyslipidemia. The hazard ratios were 1.07 for tertile 2 (95% CI 0.90-1.26) and 1.27 for tertile 3 (95% CI 1.06-1.51) compared with the reference group of tertile 1 (p = 0.009).

Conclusion

The WBC count was associated with future development of hypertension in the general Japanese population.

SUBMITTER: Ishida S

PROVIDER: S-EPMC7853436 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.

Ishida Shintaro S Kondo Seiji S Funakoshi Shunsuke S Satoh Atsushi A Maeda Toshiki T Kawazoe Miki M Yoshimura Chikara C Tada Kazuhiro K Takahashi Koji K Ito Kenji K Yasuno Tetsuhiko T Masutani Kosuke K Nakashima Hitoshi H Arima Hisatomi H

PloS one 20210202 2

<h4>Objectives</h4>This study aimed to clarify the relationship between the white blood cell (WBC) count and hypertension in the general Japanese population.<h4>Methods</h4>We conducted a population-based retrospective cohort study using annual health check-up data of residents of Iki City, Nagasaki Prefecture, Japan. A total of 2935 participants without hypertension at baseline were included in the present analysis. WBC counts were classified as tertile 1 (<4700/μL), tertile 2 (4700-5999/μL), a ...[more]

PMID: 33529192

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Dataset Information

White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.

Objectives

Methods

Result

Conclusion

Publications

White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.

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