Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions.

ABSTRACT: As a well-established multidrug combinations schema, traditional Chinese medicine (herbal prescription) has been used for thousands of years in real-world clinical settings. This paper uses a complex network approach to investigate the regularities underlying multidrug combinations in herbal prescriptions. Using five collected large-scale real-world clinical herbal prescription datasets, we construct five weighted herbal combination networks with herb as nodes and herbal combinational use in herbal prescription as links. We found that the weight distribution of herbal combinations displays a clear power law, which means that most herb pairs were used in low frequency and some herb pairs were used in very high frequency. Furthermore, we found that it displays a clear linear negative correla

SUBMITTER: Wang N 

PROVIDER: S-EPMC7854460 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature