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M⁶A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis.

ABSTRACT: Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N⁶-methyladenosine (m⁶A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m⁶A methyltransferase-like 3 (METTL3) gave rise to the upregulation of LINC00958 by promoting its RNA transcript stability. Moreover, LINC00958 acted as a competitive endogenous RNA for miR-378a-3p to promote YY1. Overall, these data provide novel insight into how m⁶A-mediated LINC00958 regulates BC tumorigenesis.

SUBMITTER: Rong D

PROVIDER: S-EPMC7854648 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis.

Rong Dongwen D Dong Qian Q Qu Huajun H Deng Xinna X Gao Fei F Li Qingxia Q Sun Ping P

Cell death discovery 20210202 1

Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N6-methyladenosine (m6A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m6A methyltransferase-like 3 (METTL3) gave rise ...[more]

PMID: 33531456

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