Dataset Information

Gains in aerobic capacity with whole-body functional electrical stimulation row training and generalization to arms-only exercise after spinal cord injury.

ABSTRACT:

Study design

Longitudinal study in adults (n?=?27; 19-40 years old) with tetraplegic or paraplegic spinal cord injury (SCI).

Objectives

Determine physiological adaptations and generalizable fitness effects of 6 months of whole-body exercise training using volitional arm and functional electrical stimulation (FES) leg rowing.

Setting

Outpatient hospital-based exercise facility and laboratory.

Methods

Participants enrolled in hybrid FES-row training (FESRT) and performed peak exercise tests with arms-only (AO; baseline and 6 months) and FES rowing (baseline, 3, 6 months).

Results

Participants demonstrated increased aerobic capacity (VO_2peak) after FESRT (p?p²?=?0.56) that tended to be higher when assessed with FES than AO rowing tests (0.15?±?0.20 vs. 0.04?±?0.22?L/min; p?=?0.10). Changes in FES and AO VO_2peak were significantly correlated (r?=?0.55; p?6%) on both test formats. Younger age was the only difference between those who showed generalization of training effects and those who did not (mean age 26.6?±?5.6 vs. 32.0?±?5.7 years; p?2peak correlated to time since injury in individuals <2 years post-SCI (r?=?-0.51, p?2peak improvements were greater during the first 3 months vs. months 4-6 (+7.0% vs. +3.9%; p?ConclusionsGains in aerobic capacity after whole-body FESRT are better reflected during FES-row testing format. They relate to high-intensity exercise and appear early during training, but they may not generalize to equivalent increases in AO exercise in all individuals with SCI.

SUBMITTER: Mercier HW

PROVIDER: S-EPMC7855132 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Gains in aerobic capacity with whole-body functional electrical stimulation row training and generalization to arms-only exercise after spinal cord injury.

Mercier Hannah W HW Picard Glen G Taylor J Andrew JA Vivodtzev Isabelle I

Spinal cord 20200727 1

<h4>Study design</h4>Longitudinal study in adults (n = 27; 19-40 years old) with tetraplegic or paraplegic spinal cord injury (SCI).<h4>Objectives</h4>Determine physiological adaptations and generalizable fitness effects of 6 months of whole-body exercise training using volitional arm and functional electrical stimulation (FES) leg rowing.<h4>Setting</h4>Outpatient hospital-based exercise facility and laboratory.<h4>Methods</h4>Participants enrolled in hybrid FES-row training (FESRT) and perform ...[more]

PMID: 32719528

Similar Datasets

Project description:Epidural electrical stimulation can restore limb motor function after spinal cord injury by reactivating the surviving neural circuits. In previous epidural electrical stimulation studies, single electrode sites and continuous tetanic stimulation have often been used. With this stimulation, the body is prone to declines in tolerance and locomotion coordination. In the present study, rat models of complete spinal cord injury were established by vertically cutting the spinal cord at the T8 level to eliminate disturbance from residual nerve fibers, and were then subjected to epidural electrical stimulation. The flexible extradural electrode had good anatomical topology and matched the shape of the spinal canal of the implanted segment. Simultaneously, the electrode stimulation site was able to be accurately applied to the L2-3 and S1 segments of the spinal cord. To evaluate the biocompatibility of the implanted epidural electrical stimulation electrodes, GFAP/Iba-1 double-labeled immunofluorescence staining was performed on the spinal cord below the electrodes at 7 days after the electrode implantation. Immunofluorescence results revealed no significant differences in the numbers or morphologies of microglia and astrocytes in the spinal cord after electrode implantation, and there was no activated Iba-1+ cell aggregation, indicating that the implant did not cause an inflammatory response in the spinal cord. Rat gait analysis showed that, at 3 days after surgery, gait became coordinated in rats with spinal cord injury under burst stimulation. The regained locomotion could clearly distinguish the support phase and the swing phase and dynamically adjust with the frequency of stimulus distribution. To evaluate the matching degree between the flexible epidural electrode (including three stimulation contacts), vertebral morphology, and the level of the epidural site of the stimulation electrode, micro-CT was used to scan the thoracolumbar vertebrae of rats before and after electrode implantation. Based on the experimental results of gait recovery using three-site stimulation electrodes at L2-3 and S1 combined with burst stimulation in a rat model of spinal cord injury, epidural electrical stimulation is a promising protocol that needs to be further explored. This study was approved by the Animal Ethics Committee of Chinese PLA General Hospital (approval No. 2019-X15-39) on April 19, 2019.

Dataset Information

Gains in aerobic capacity with whole-body functional electrical stimulation row training and generalization to arms-only exercise after spinal cord injury.

Study design

Objectives

Setting

Methods

Results

Publications

Gains in aerobic capacity with whole-body functional electrical stimulation row training and generalization to arms-only exercise after spinal cord injury.

Similar Datasets

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