Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer's disease.

ABSTRACT: A majority of patients with Alzheimer's disease (AD) experience some form of sleep disruption, including nocturnal sleep fragmentation, increased daytime napping, decreased slow-wave sleep (SWS, stage N3), and decreased rapid-eye-movement sleep (REM). Clinical studies are investigating whether such sleep disturbances are a consequence of the underlying disease, and whether they also contribute to the clinical and pathological manifestations of AD. Emerging research has provided a direct link between several of these sleep disruptions and AD pathophysiology, suggesting that treating sleep disorders in this population may target basic mechanisms of the disease. Here, we provide a comprehensive review of sleep disturbances associated with the spectrum of AD, ranging from the preclinical stage

SUBMITTER: Kent BA 

PROVIDER: S-EPMC7855222 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature