Testing Strategies and Predictors for Evaluating Immediate and Delayed Reactions to Cephalosporins.

ABSTRACT:

Background

Although 1% to 2% of the general population carries a cephalosporin allergy label (CAL), we lack validated testing strategies and predictors of true allergy.

Objective

To identify cross-reactivity patterns and predictors of skin test positive (STP) in geographically disparate patients with a CAL.

Methods

A total of 780 adult patients labeled with a CAL or penicillin allergy label (PAL) with unknown tolerance of cephalosporins identified from the Austin Hospital (Melbourne, Australia) (n = 410) and Vanderbilt University Medical Center (Nashville, TN) (n = 370) between 2014 and 2018 underwent a standardized skin testing.

Results

Of 328 patients with a CAL, 29 (8.8%) tested STP to ≥1 cephalosporin(s). There were no cefazolin or ceftriaxone STP, 0 of 452

SUBMITTER: Stone CA 

PROVIDER: S-EPMC7855229 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature