Ontology highlight
ABSTRACT:
SUBMITTER: Du Bruyn E
PROVIDER: S-EPMC7855386 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Du Bruyn Elsa E Ruzive Sheena S Lindestam Arlehamn Cecilia S CS Sette Alessandro A Sher Alan A Barber Daniel L DL Wilkinson Robert J RJ Riou Catherine C
Mucosal immunology 20200716 2
Recent data from mice and non-human primate models of tuberculosis suggested that CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis (Mtb) control. However, this molecule has not been comprehensively evaluated in humans. Here, we show that the proportion of Mtb-specific CD4 T cells expressing CD153 was significantly reduced in active TB patients compared to latently infected persons. Importantly, the CD153+ Mtb-specific CD4 response inversely correlated with ...[more]