Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC7855694 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cell chemical biology 20201013 1
Despite widespread interest for understanding how modified bases have evolved their contemporary functions, limited experimental evidence exists for measuring how close an organism is to accidentally creating a new, modified base within the framework of its existing genome. Here, we describe the biochemical and structural basis for how a single-point mutation in E. coli's naturally occurring cytosine methyltransferase can surprisingly endow a neomorphic ability to create the unnatural DNA base, ...[more]