Ontology highlight
ABSTRACT:
SUBMITTER: Han A
PROVIDER: S-EPMC7856044 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Han Anna A Purwin Timothy J TJ Bechtel Nelisa N Liao Connie C Chua Vivian V Seifert Erin E Sato Takami T Schug Zachary T ZT Speicher David W DW Harbour J William JW Aplin Andrew E AE
Oncogene 20201118 3
Cancer cell metabolism is a targetable vulnerability; however, a precise understanding of metabolic heterogeneity is required. Inactivating mutations in BRCA1-associated protein 1 (BAP1) are associated with metastasis in uveal melanoma (UM), the deadliest adult eye cancer. BAP1 functions in UM remain unclear. UM patient sample analysis divided BAP1 mutant UM tumors into two subgroups based on oxidative phosphorylation (OXPHOS) gene expression suggesting metabolic heterogeneity. Consistent with p ...[more]