Ontology highlight
ABSTRACT:
SUBMITTER: Medved J
PROVIDER: S-EPMC7856068 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Medved Jelena J Wood William M WM van Heyst Michael D MD Sherafat Amin A Song Ju-Young JY Sakya Sagune S Wright Dennis L DL Nishiyama Akiko A
Glia 20201024 3
Oligodendrocyte precursor cells (OPCs), also known as NG2 cells or polydendrocytes, are distributed widely throughout the developing and mature central nervous system. They remain proliferative throughout life and are an important source of myelinating cells in normal and demyelinating brain as well as a source of glioma, the most common type of primary brain tumor with a poor prognosis. OPC proliferation is dependent on signaling mediated by platelet-derived growth factor (PDGF) AA binding to i ...[more]