Estimation of load conditions and strain distribution for in vivo murine tibia compression loading using experimentally informed finite element models.

ABSTRACT: The murine tibia compression model, is the gold standard for studying bone adaptation due to mechanical loading in vivo. Currently, a key limitation of the experimental protocol and associated finite element (FE) models is that the exact load transfer, and consequently the loading conditions on the tibial plateau, is unknown. Often in FE models, load is applied to the tibial plateau based on inferences from micro-computed tomography (μCT). Experimental models often use a single strain gauge to assess the three-dimensional (3D) loading state. However, a single strain gauge is insufficient to validate such FE models. To address this challenge, we develop an experimentally calibrated method for identifying the load application region on the tibial plateau based upon measurements from three st

SUBMITTER: Pickering E 

PROVIDER: S-EPMC7856106 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature