Dataset Information

Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models?

ABSTRACT: Deep partial thickness burns are clinically prevalent and difficult to diagnose. In order to develop methods to assess burn depth and therapies to treat deep partial thickness burns, reliable, accurate animal models are needed. The variety of animal models in the literature and the lack of precise details reported for the experimental procedures makes comparison of research between investigators challenging, and ultimately impacts translation to patients. We sought to compare deep partial thickness porcine burn models from five well-established laboratories. In doing so, we uncovered a lack of consistency in approaches to the evaluation of burn injury depth that was present within and among various models. We then used an iterative process to develop a scoring rubric with an educational component to facilitate burn injury depth evaluation that improved reliability of the scoring. Using the developed rubric to re-score the five burn models, we found that all models created a deep partial thickness injury and that agreement about specific characteristics identified on histologic staining was improved. Finally, we present consensus statements on the evaluation and interpretation of the microanatomy of deep partial thickness burns in pigs.

SUBMITTER: Gibson ALF

PROVIDER: S-EPMC7856457 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models?

Gibson Angela L F ALF Carney Bonnie C BC Cuttle Leila L Andrews Christine J CJ Kowalczewski Christine J CJ Liu Aiping A Powell Heather M HM Stone Randolph R Supp Dorothy M DM Singer Adam J AJ Shupp Jeffrey W JW Stalter Lily L Moffatt Lauren T LT

Journal of burn care & research : official publication of the American Burn Association 20210201 1

Deep partial thickness burns are clinically prevalent and difficult to diagnose. In order to develop methods to assess burn depth and therapies to treat deep partial thickness burns, reliable, accurate animal models are needed. The variety of animal models in the literature and the lack of precise details reported for the experimental procedures make comparison of research between investigators challenging and ultimately affect translation to patients. They sought to compare deep partial thickne ...[more]

PMID: 32835360

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Dataset Information

Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models?

Publications

Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models?

Similar Datasets

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