Unknown

Dataset Information

0

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.

ABSTRACT: An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019 (COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 and REGN10933) that targets nonoverlapping epitopes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in the lower and upper airways and decrease virus-induced pathological sequelae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.

SUBMITTER: Baum A 

PROVIDER: S-EPMC7857396 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.

Baum Alina A   Ajithdoss Dharani D   Copin Richard R   Zhou Anbo A   Lanza Kathryn K   Negron Nicole N   Ni Min M   Wei Yi Y   Mohammadi Kusha K   Musser Bret B   Atwal Gurinder S GS   Oyejide Adelekan A   Goez-Gazi Yenny Y   Dutton John J   Clemmons Elizabeth E   Staples Hilary M HM   Bartley Carmen C   Klaffke Benjamin B   Alfson Kendra K   Gazi Michal M   Gonzalez Olga O   Dick Edward E   Carrion Ricardo R   Pessaint Laurent L   Porto Maciel M   Cook Anthony A   Brown Renita R   Ali Vaneesha V   Greenhouse Jack J   Taylor Tammy T   Andersen Hanne H   Lewis Mark G MG   Stahl Neil N   Murphy Andrew J AJ   Yancopoulos George D GD   Kyratsous Christos A CA  

Science (New York, N.Y.) 20201009 6520

An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019 (COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 and REGN10933) that targets nonoverlapping epitopes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, whi  ...[more]

Similar Datasets

Unknown Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques.
| S-EPMC9020736 | biostudies-literature
Unknown Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques.
| S-EPMC8166510 | biostudies-literature
Unknown Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation.
| S-EPMC8523485 | biostudies-literature
Unknown REGN-COV2 antibody cocktail in patients with SARS-CoV-2: Observational study from a single institution in Japan.
| S-EPMC8986486 | biostudies-literature
Unknown A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2-specific immune responses in rhesus macaques.
| S-EPMC9802654 | biostudies-literature
Unknown Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2.
| S-EPMC7301902 | biostudies-literature
Unknown SARS-CoV-2 infection protects against rechallenge in rhesus macaques.
| S-EPMC7243369 | biostudies-literature
Unknown Correlates of protection against SARS-CoV-2 in rhesus macaques.
| S-EPMC7906955 | biostudies-literature
Unknown Respiratory disease in rhesus macaques inoculated with SARS-CoV-2.
| S-EPMC7486227 | biostudies-literature
Transcriptomics Ad26.COV2.S Prevents SARS-CoV-2 Induced Pathways of Inflammation and Thrombosis in Hamsters
2022-03-26 | GSE196893 | GEO