Ontology highlight
ABSTRACT:
SUBMITTER: Baum A
PROVIDER: S-EPMC7857396 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20201009 6520
An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019 (COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 and REGN10933) that targets nonoverlapping epitopes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, whi ...[more]