Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF.
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ABSTRACT:
SUBMITTER: Yoshizaki K
PROVIDER: S-EPMC7857438 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF.
Yoshizaki Kaichi K Kimura Ryuichi R Kobayashi Hisato H Oki Shinya S Kikkawa Takako T Mai Lingling L Koike Kohei K Mochizuki Kentaro K Inada Hitoshi H Matsui Yasuhisa Y Kono Tomohiro T Osumi Noriko N
EMBO reports 20210105 2
Advanced paternal age can have deleterious effects on various traits in the next generation. Here, we establish a paternal-aging model in mice to understand the molecular mechanisms of transgenerational epigenetics. Whole-genome target DNA methylome analyses of sperm from aged mice reveal more hypo-methylated genomic regions enriched in REST/NRSF binding motifs. Gene set enrichment analyses also reveal the upregulation of REST/NRSF target genes in the forebrain of embryos from aged fathers. Offs ...[more]
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