Ontology highlight
ABSTRACT:
SUBMITTER: Pedersen DV
PROVIDER: S-EPMC7857727 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Pedersen Dennis V DV Pedersen Martin Nors MN Mazarakis Sofia Mm SM Wang Yong Y Lindorff-Larsen Kresten K Arleth Lise L Andersen Gregers R GR
eLife 20210122
Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links to function remains unknown. We show by combining electron microscopy and solution scattering, that properdin oligomers adopt extended rigid and well-defined conformations which are well approximated by single models of apparent n-fold rotationa ...[more]