Dataset Information

Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.

ABSTRACT:

Background

Uromodulin, a tissue-specific tubular glycoprotein, has recently emerged as a promising biomarker for kidney function and tubular integrity. However, the association of serum uromodulin (sUmod) with renal function decline is still unknown in an older general population.

Methods

We analysed the association of sUmod with the estimated glomerular filtration rate (eGFR) and albuminuria in 1075 participants of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study, ages 62-81?years, at baseline and prospectively after a mean follow-up time of 6.5?years (n?=?605) using logistic and linear regression models as well as receiver operating characteristics (ROC) analyses.

Results

Cross-sectionally, sUmod was positively associated with eGFR (??=?0.31?±?0.02 per higher standard deviation sUmod; P?2 after 6.5?years of follow-up {odds ratio [OR] 1.02 [95% confidence interval (CI) 0.77-1.36] per higher SD sUmod} but was inversely associated with advanced CKD, defined as incident eGFR <45?mL/min/1.73?m² [OR 0.64 (95% CI 0.42-0.98)]. The ROC showed no added predictive value of sUmod for kidney function decline in the fully adjusted model.

Conclusions

Higher sUmod was inversely associated with progression to advanced kidney disease but does not provide additional predictive value for the development of CKD in elderly participants of the population-based KORA study.

SUBMITTER: Then C

PROVIDER: S-EPMC7857794 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.

Then Cornelia C Then Holger L HL Lechner Andreas A Thorand Barbara B Meisinger Christa C Heier Margit M Peters Annette A Koenig Wolfgang W Rathmann Wolfgang W Scherberich Jürgen J Seissler Jochen J

Clinical kidney journal 20200501 1

<h4>Background</h4>Uromodulin, a tissue-specific tubular glycoprotein, has recently emerged as a promising biomarker for kidney function and tubular integrity. However, the association of serum uromodulin (sUmod) with renal function decline is still unknown in an older general population.<h4>Methods</h4>We analysed the association of sUmod with the estimated glomerular filtration rate (eGFR) and albuminuria in 1075 participants of the population-based Cooperative Health Research in the Region of ...[more]

PMID: 33564420

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Dataset Information

Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.

Background

Methods

Results

Conclusions

Publications

Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.

Similar Datasets

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