Ontology highlight
ABSTRACT:
SUBMITTER: Aguado C
PROVIDER: S-EPMC7858100 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Aguado Cristina C Teixido Cristina C Román Ruth R Reyes Roxana R Giménez-Capitán Ana A Marin Elba E Cabrera Carlos C Viñolas Nuria N Castillo Sergi S Muñoz Silvia S Arcocha Ainara A López-Vilaró Laura L Sullivan Ivana I Aldeguer Erika E Rodríguez Sonia S Moya Irene I Viteri Santiago S Cardona Andrés Felipe AF Palmero Ramon R Sainz Cristina C Mesa-Guzmán Miguel M Lozano Maria D MD Aguilar-Hernández Andrés A Martínez-Bueno Alejandro A González-Cao María M Gonzalvo Elena E Leenders William P J WPJ Rosell Rafael R Montuenga Luis M LM Prat Aleix A Molina-Vila Miguel A MA Reguart Noemi N
Molecular oncology 20201207 2
MET inhibitors have shown activity in non-small-cell lung cancer patients (NSCLC) with MET amplification and exon 14 skipping (METΔex14). However, patient stratification is imperfect, and thus, response rates have varied widely. Here, we studied MET alterations in 474 advanced NSCLC patients by nCounter, an RNA-based technique, together with next-generation sequencing (NGS), fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and reverse transcriptase polymerase chain reaction ...[more]