Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest.
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ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC7858282 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest.
Zhang Huanyu H Zhang Zhe Z Huang Yonghao Y Qin Siyuan S Zhou Li L Weng Ningna N Liu Jiayang J Yang Mei M Zhang Xiaodian X Lu Yanda Y Ma Lin L Zheng Shaojiang S Li Qifu Q
Molecular oncology 20201212 2
Pancreatic cancer (PC) is one of the most common human malignancies worldwide and remains a major clinical challenge. Here, we found that benproperine phosphate (BPP), a cough suppressant, showed a significant anticancer effect on PC both in vitro and in vivo via the induction of autophagy-mediated cell death. Mechanistic studies revealed that BPP triggered AMPK/mTOR-mediated autophagy initiation and disturbed Ras-related protein Rab-11A (RAB11A)-mediated autophagosome-lysosome fusion, resulting ...[more]
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