[Diagnosis and therapy of tumors with NTRK gene fusion].
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ABSTRACT:
SUBMITTER: Stenzinger A
PROVIDER: S-EPMC7858552 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
[Diagnosis and therapy of tumors with NTRK gene fusion].
Stenzinger Albrecht A van Tilburg Cornelis M CM Tabatabai Ghazaleh G Länger Florian F Graf Norbert N Griesinger Frank F Heukamp Lukas C LC Hummel Michael M Klingebiel Thomas T Hettmer Simone S Vokuhl Christian C Merkelbach-Bruse Sabine S Overkamp Friedrich F Reichardt Peter P Scheer Monika M Weichert Wilko W Westphalen C Benedikt CB Bokemeyer Carsten C Ivanyi Philipp P Loges Sonja S Schirmacher Peter P Wörmann Bernhard B Bielack Stefan S Seufferlein Thomas T W TTW
Der Pathologe 20210201 1
NTRK gene fusions are sporadic genetic alterations that can occur across tumor entities. Whereas they are quite rare in most solid tumors they are present at much higher frequencies in certain rare tumors such as infantile fibrosarcoma, congenital mesoblastic nephroma, secretory breast, or salivary gland carcinoma. NTRK gene fusions or TRK fusion proteins are considered strong oncogenic drivers. If NTRK gene fusions are detected, TRK inhibitors such as entrectinib and larotrectinib can be used r ...[more]
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