Differential DNA methylation in recovery from shift work disorder.

ABSTRACT: The human DNA methylome is responsive to our environment, but its dynamics remain underexplored. We investigated the temporal changes to DNA methylation (DNAme) in relation to recovery from a shift work disorder (SWD) by performing a paired epigenome-wide analysis in an occupational cohort of 32 shift workers (25 men, age?=?43.8?±?8.8 years, 21 SWD cases). We found that the effect of vacation on DNAme was more prominent in the SWD-group as compared to controls, with respect to the amount of significantly differentially methylated positions (DMPs; P_unadj?FDR?unadj?

SUBMITTER: Lahtinen A 

PROVIDER: S-EPMC7858604 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature