Differential DNA methylation in recovery from shift work disorder.
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ABSTRACT:
SUBMITTER: Lahtinen A
PROVIDER: S-EPMC7858604 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Differential DNA methylation in recovery from shift work disorder.
Lahtinen Alexandra A Häkkinen Antti A Puttonen Sampsa S Vanttola Päivi P Viitasalo Katriina K Porkka-Heiskanen Tarja T Härmä Mikko M Paunio Tiina T
Scientific reports 20210203 1
The human DNA methylome is responsive to our environment, but its dynamics remain underexplored. We investigated the temporal changes to DNA methylation (DNAme) in relation to recovery from a shift work disorder (SWD) by performing a paired epigenome-wide analysis in an occupational cohort of 32 shift workers (25 men, age = 43.8 ± 8.8 years, 21 SWD cases). We found that the effect of vacation on DNAme was more prominent in the SWD-group as compared to controls, with respect to the amount of sign ...[more]
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