Ontology highlight
ABSTRACT:
SUBMITTER: Mathew R
PROVIDER: S-EPMC7858622 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Mathew Rency R Wunderlich Juliane J Thivierge Karine K Cwiklinski Krystyna K Dumont Claire C Tilley Leann L Rohrbach Petra P Dalton John P JP
Scientific reports 20210203 1
The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, PfM1AAP and PfM17LAP, are potential targets for novel anti-malarial drug development. Inhibitors of these aminopeptidases have been shown to kill malaria parasites in culture and reduce parasite growth in murine models. The two enzymes may function in the terminal stages of haemoglobin digestion, providing free amino acids for protein synthesis by the rapidly growing intra-erythrocytic parasites. Here we have perfo ...[more]