Dataset Information

Lithium exposure during pregnancy increases fetal growth.

ABSTRACT:

Background

Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse in bipolar disorder, but there is a lack of knowledge about the potential adverse impact on fetal development.

Aims

To investigate the impact of lithium exposure on early fetal growth.

Methods

In this retrospective observational cohort study, we included all singleton pregnancies of women using lithium and referred for advanced fetal ultrasound scanning between 1994 and 2018 to the University Medical Centers in Leiden and Rotterdam, the Netherlands (n=119). The Generation R study, a population-based cohort, served as a non-exposed control population from the same geographic region (n=8184). Fetal head circumference, abdominal circumference, femur length, and transcerebellar diameter were measured by ultrasound at 18-22?weeks of gestation.

Results

Lithium use during pregnancy was associated with an average increase in head circumference of 1.77?mm (95% confidence interval: 0.53, 3.01), in abdominal circumference of 5.54?mm (95% confidence interval: 3.95, 7.12) and in femur length of 0.59?mm (95% confidence interval: 0.22, 0.96) at 18-22?weeks gestation. Furthermore, lithium use during pregnancy was associated with an average increase in birth weight of 142.43?grams (95% confidence interval: 58.01, 226.89), whereas it was associated with an average decrease of 1.41?weeks in gestational duration (95% confidence interval: -1.78, -1.05).

Conclusions

Lithium use during pregnancy was associated with increased fetal growth parameters at 18-22?weeks gestational age and increased birth weight. Further research is needed to evaluate both short- and long-term implications, as well as the mechanisms driving this difference in growth.

SUBMITTER: Poels EM

PROVIDER: S-EPMC7859661 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Lithium exposure during pregnancy increases fetal growth.

Poels Eline Mp EM Sterrenburg Karin K Wierdsma André I AI Wesseloo Richard R Beerthuizen Annemerle A van Dijke Laura L Lau Condon C Hoogendijk Witte Jg WJ Marroun Hanan El HE van Kamp Inge L IL Bijma Hilmar H HH Bergink Veerle V

Journal of psychopharmacology (Oxford, England) 20200720 2

<h4>Background</h4>Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse in bipolar disorder, but there is a lack of knowledge about the potential adverse impact on fetal development.<h4>Aims</h4>To investigate the impact of lithium exposure on early fetal growth.<h4>Methods</h4>In this retrospective observational cohort study, we included all singleton pregnancies of women using lithium and referred for advanced fetal ultrasound scanning between 1994 and 20 ...[more]

PMID: 32684118

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Dataset Information

Lithium exposure during pregnancy increases fetal growth.

Background

Aims

Methods

Results

Conclusions

Publications

Lithium exposure during pregnancy increases fetal growth.

Similar Datasets

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