fruitless tunes functional flexibility of courtship circuitry during development.

ABSTRACT: Drosophila male courtship is controlled by the male-specific products of the fruitless (fru^M) gene and its expressing neuronal circuitry. fru^M is considered a master gene that controls all aspects of male courtship. By temporally and spatially manipulating fru^M expression, we found that fru^M is required during a critical developmental period for innate courtship toward females, while its function during adulthood is involved in inhibiting male-male courtship. By altering or eliminating fru^M expression, we generated males that are innately heterosexual, homosexual, bisexual, or without innate courtship but could acquire such behavior in an experience-dependent manner. These findings show that fru^M is not absolutely necessary for courtship but is critical during development to build a sex circuitry with reduced flexibility and enhanced efficiency, and provide a new view about how fru^M tunes functional flexibility of a sex circuitry instead of switching on its function as conventionally viewed.

SUBMITTER: Chen J 

PROVIDER: S-EPMC7861613 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature