Unknown

Dataset Information

0

Serological evidence indicates widespread distribution of rickettsioses in Myanmar.


ABSTRACT:

Background

Little research has been published on the prevalence of rickettsial infections in Myanmar. This study determined the seroprevalence of immunoglobulin G (IgG) antibodies to rickettsial species in different regions of Myanmar.

Methods

Seven hundred leftover blood samples from patients of all ages in primary care clinics and hospitals in seven regions of Myanmar were collected. Samples were screened for scrub typhus group (STG), typhus group (TG) and spotted fever group (SFG) IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Immunofluorescence assays were performed for the same rickettsial groups to confirm seropositivity if ELISA optical density ?0.5.

Results

Overall IgG seroprevalence was 19% [95% confidence interval (CI) 16-22%] for STG, 5% (95% CI 3-7%) for TG and 3% (95% CI: 2-5%) for SFG. The seroprevalence of STG was particularly high in northern and central Myanmar (59% and 19-33%, respectively). Increasing age was associated with higher odds of STG and TG seropositivity [per 10-year increase, adjusted odds ratio estimate 1.68 (p < 0.01) and 1.24 (p = 0.03), respectively].

Conclusion

Rickettsial infections are widespread in Myanmar, with particularly high seroprevalence of STG IgG antibodies in central and northern regions. Healthcare workers should consider rickettsial infections as common causes of fever in Myanmar.

SUBMITTER: Elders PND 

PROVIDER: S-EPMC7862081 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Serological evidence indicates widespread distribution of rickettsioses in Myanmar.

Elders Philip N D PND   Swe Myo Maung Maung MMM   Phyo Aung Pyae AP   McLean Alistair R D ARD   Lin Htet Naing HN   Soe Kyaw K   Htay Wei Yan Aung WYA   Tanganuchitcharnchai Ampai A   Hla Thel K TK   Tun Ni Ni NN   Nwe Thin Thin TT   Moe Myat Myat MM   Thein Win May WM   Zaw Ni Ni NN   Kyaw Wai Mon WM   Linn Htun H   Htwe Yin Yin YY   Smithuis Frank M FM   Blacksell Stuart D SD   Ashley Elizabeth A EA  

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20201211


<h4>Background</h4>Little research has been published on the prevalence of rickettsial infections in Myanmar. This study determined the seroprevalence of immunoglobulin G (IgG) antibodies to rickettsial species in different regions of Myanmar.<h4>Methods</h4>Seven hundred leftover blood samples from patients of all ages in primary care clinics and hospitals in seven regions of Myanmar were collected. Samples were screened for scrub typhus group (STG), typhus group (TG) and spotted fever group (S  ...[more]

Similar Datasets

| S-EPMC8402696 | biostudies-literature
| S-EPMC3737326 | biostudies-literature
| S-EPMC6040755 | biostudies-literature
| S-EPMC3923745 | biostudies-literature
| S-EPMC8161608 | biostudies-literature
| S-EPMC3409466 | biostudies-literature
| S-EPMC3243060 | biostudies-literature
2012-05-31 | GSE37232 | GEO
| S-EPMC5404336 | biostudies-literature
| S-EPMC2737902 | biostudies-literature