The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men.
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ABSTRACT:
SUBMITTER: Altakroni B
PROVIDER: S-EPMC7862252 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men.
Altakroni B B Nevin C C Carroll M M Murgatroyd C C Horne G G Brison D R DR Povey A C AC
Scientific reports 20210204 1
Sperm DNA contains a range of DNA base damage that can arise, in part, from exposure to methylating agents. However, the effects are not fully characterized and so the aim of this study was to investigate associations between semen quality and the levels of N7-methyldeoxyguanosine (N7-MedG), a marker of exposure to methylating agents, and other markers of DNA damage and DNA methylation. Sperm samples were collected from 105 men attending an assisted reproduction clinic as part of a couple underg ...[more]
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