Ontology highlight
ABSTRACT:
SUBMITTER: Kovacevic KD
PROVIDER: S-EPMC7862663 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kovacevic Katarina D KD Greisenegger Stefan S Langer Agnes A Gelbenegger Georg G Buchtele Nina N Pabinger Ingrid I Petroczi Karin K Zhu Shuhao S Gilbert James C JC Jilma Bernd B
Scientific reports 20210204 1
The effect of conventional anti-platelet agents is limited in secondary stroke prevention, and their effects are blunted under high shear stress in the presence of increased levels of circulating von Willebrand factor (VWF). VWF is critically involved in thrombus formation at sites of stenotic extracranial/intracranial arteries. A third generation anti-VWF aptamer (BT200) has been generated which could be useful for secondary stroke prevention. To characterize the effects of BT200 in blood of pa ...[more]