Ontology highlight
ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC7862758 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yang Dongshan D Liang Xiubin X Pallas Brooke B Hoenerhoff Mark M Ren Zhuoying Z Han Renzhi R Zhang Jifeng J Chen Y Eugene YE Jin Jian-Ping JP Sun Fei F Xu Jie J
Frontiers in genetics 20210122
Cystic Fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation is the deletion of phenylalanine residue at position 508 (ΔF508). Here we report the production of CFTR-ΔF508 rabbits by CRISPR/Cas9-mediated gene editing. After microinjection and embryo transfer, 77 kits were born, of which five carried the ΔF508 mutation. To confirm the germline transmission, one male ΔF5 ...[more]