Unknown

Dataset Information

0

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.


ABSTRACT: SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or convalescent time points, up to 102 days after symptom onset, quantifying 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18, and IL-10 and broad activation marked by the upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3+cTFH1 cells in acute COVID-19 significantly correlate with and predict antibody levels and their avidity at convalescence as well as acute neutralization activity. Strikingly, intensive care unit (ICU) patients with severe COVID-19 display higher levels of soluble IL-6, IL-6R, and IL-18, and hyperactivation of innate, adaptive, and myeloid compartments than patients with moderate disease. Our analyses provide a comprehensive map of longitudinal immunological responses in COVID-19 patients and integrate key cellular pathways of complex immune networks underpinning severe COVID-19, providing important insights into potential biomarkers and immunotherapies.

SUBMITTER: Koutsakos M 

PROVIDER: S-EPMC7862905 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7686651 | biostudies-literature
| S-EPMC7908880 | biostudies-literature
| S-EPMC7491535 | biostudies-literature
| S-EPMC7919849 | biostudies-literature
2024-09-20 | GSE246795 | GEO
| S-EPMC8009921 | biostudies-literature
| S-EPMC7454292 | biostudies-literature
| S-EPMC8939764 | biostudies-literature
2023-01-12 | GSE199750 | GEO
| S-EPMC7464057 | biostudies-literature