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Olanzapine-Associated Rhabdomyolysis: A Case Report.

ABSTRACT: This paper presents the case of a 20-year-old patient with a suspected diagnosis of paranoid schizophrenia. He was prescribed oral olanzapine at a dose of 10 mg per day, and the treatment was associated with rhabdomyolysis (serum creatine kinase = 9,725 U/L on day four of the therapy). On suspicion of its contribution to rhabdomyolysis, olanzapine was immediately withdrawn. Pharmacogenetic testing demonstrated that the patient's CYP2D6 genotype was *4/*4 (1846G>A, rs3892097). Based on these results, the patient was switched to trifluoperazine, a medication that is not metabolized by the CYP2D6 isoenzyme. Subsequently, the patient recovered well and was discharged without any nephrological sequelae. The presented case demonstrates that pharmacogenetic-guided personalization of treatment may allow selecting the best medication and determining the right dosage, resulting in the reduced risk of adverse drug reactions and pharmacoresistance.

SUBMITTER: Skryabin VY

PROVIDER: S-EPMC7863024 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Olanzapine-Associated Rhabdomyolysis: A Case Report.

Skryabin Valentin Y VY Zastrozhin Michael M Sychev Dmitry A DA

Cureus 20210108 1

This paper presents the case of a 20-year-old patient with a suspected diagnosis of paranoid schizophrenia. He was prescribed oral olanzapine at a dose of 10 mg per day, and the treatment was associated with rhabdomyolysis (serum creatine kinase = 9,725 U/L on day four of the therapy). On suspicion of its contribution to rhabdomyolysis, olanzapine was immediately withdrawn. Pharmacogenetic testing demonstrated that the patient's <i>CYP2D6</i> genotype was <i>*4/*4 (1846G>A, rs3892097)</i>. Based ...[more]

PMID: 33564555

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