Ontology highlight
ABSTRACT:
SUBMITTER: Chasse MH
PROVIDER: S-EPMC7863405 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Chasse Maggie H MH Johnson Benjamin K BK Boguslawski Elissa A EA Sorensen Katie M KM Rosien Jessica E JE Kang Min H MH Reynolds C Patrick CP Heo Lyong L Madaj Zachary B ZB Beddows Ian I Foxa Gabrielle E GE Kitchen-Goosen Susan M SM Williams Bart O BO Triche Timothy J TJ Grohar Patrick J PJ
EMBO molecular medicine 20201217 2
Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic options for these patients. Here we use unbiased screening of cell line panels to identify a heightened sensitivity of rhabdoid tumor to mithramycin and the second-generation analogue EC8042. The sensitivity of MMA and EC8042 was superior to traditional DNA damag ...[more]